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May 11, 2023 by ktangen

Brain Notes

Cerebellum: More Neuron In Less Space

Behind the Brain

  • Cerebellum
    • Balance and coordination
    • More neurons than rest of brain combined
    • Damage
      • Problems making rapid move
      • Anything require aim & timing
      • Point at moving object
      • Clapping hands
      • Writing, typing
      • Not good at discrete tasks
      • Good at continuous tasks
      • Drawing continuous circle

Under the Brain

The Limbic System is the brain’s brake. It works on the disinhibition principle. If it receives no input, the Limbic system produces a steady rate of firing. Without input, it releases GABA. When it receives an input, which releases glutamate, the Limbic system lowers its firing rate. Since glutamate triggers a reaction in the system, internal connections use dopamine or acetylcholine (ACh).

The Limbic System is a group of nuclei; distinct masses of gray matter.

Left-right sides mirror each other

Work together as functional unit

Interact with cortex, thalamus, etc

 

FOUR PARTS

Striatum

Dorsal

caudate & putamen

Ventral

nucleus accumbens & olfactory

Pallidum

globus pallidus (dorsal)

ventral pallidum

Substantia nigra (pons)

Subthalamic nucleus (below thalamus)

 

Two large parts

Striatum & Pallidum

Two smaller parts (& farther back)

Substantia Nigra & Subthalamic

 

Disorders

Huntington’s disease

Major loss of medium spiny neurons in striatum

Inability to prevent parts of the body from moving unintentionally

 

  1. Striatum

Largest

Looks striped

Looks like two blobs of gray separated by large white stripe

input from many brain areas

only outputs to other parts of basal ganglia

Complex internal organization

Direct pathway (D1)

Indirect (D2)

Organized in 3D

Cortex is layered; organized 2D

Coordinates multiple aspects of cognition

action planning

decision making

motivation

reinforcement

reward

 

Interneurons

Release acetylcholine

Many types of interneurons

include fast-spiking interneurons

Continuously produce new neurons in striatum

 

Striatum is activated by stimuli associated with reward

aversive

novel & unexpected

intense stimuli

 

Ventral striatum composed of olfactory tubercle & nucleus accumbens

As a whole, major role in cognitive processing of

aversion & pleasure

motivation

reward & reinforcement

addiction

As a whole, minor role

cognitive processing of:

fear (type of aversion)

impulsivity

placebo effect

Also involved in

encoding of new motor skills

Nucleus accumbens

Two, one in each hemisphere

Each has two structures:

Nucleus accumbens core

Increased density of dendritic spines

Increased branch segments

Increased terminal segments

Processes

motor function related to reward

encodes new motor programs that help get future rewards

Nucleus accumbens shell

Lower density of dendritic spines

Less terminal segments

Less branch segments

Processes

want (motivational salience)

reward perception

positive reinforcement

drugs & naturally rewarding stimuli

addictive drugs affect dopamine in shell more than core

Function

Reward

Subset of VTA neurons

Dopamine (D1) medium spiny neurons in shell

Drugs

Increase dopamine in shell & core; more pronounced in shell

morphine

cocaine

amphetamines

at high levels, increase dopamine level to similar levels in both shell & core

Drug rewards

has abnormal strengthening effect on stimulus

drug associations

increases drug-reward stimuli’s resistance to extinction

effect was more pronounced in shell than core

Addiction

Links to addictions to

alcohol, cannabinoids, cocaine

nicotine, opioids & amphetamines

Links to

Depression

OCD

Placebo effect

 

 

 

 

  1. Pallidum

Input from striatum

Sends inhibitory output to a number of motor-related areas

Globus Pallidus

Latin for “pale globe“

AKA,  paleostriatum or dorsal pallidum

Output to substantia nigra

Very large neurons

Very large dendritic arbors

3-dimensional shape of flat discs

Involved in plan & inhibit move

regulation of voluntary movement

regulate subconscious movements

If damaged, can cause movement disorders

Balances excitatory action of cerebellum

allow people to move smoothly

even & controlled movements

 

  1. Substantia Nigra

Located in pons

Important role in reward, addiction &  movement

Latin for black substance

due to high levels of neuromelanin found in dopaminergic neurons

Discovered in 1784

Largest nucleus in midbrain

Two substantiae nigrae; one on each side

Function

eye movement

motor planning

reward-seeking

learning

addiction

Mediated thru striatum

Co-dependence between striatum & substantia nigra

Looks like a continuous band

Two parts with very different connections and functions:

  1. Pars Compacta

Supplies striatum with dopamine

Heavily involved in learned responses to stimuli

Activity increases when new $ is presented

Partial dopamine deficits do not affect motor control

Can lead to disturbances in the sleep-wake cycle

Especially in hippocampus
Parkinson’s

Neurodegenerative disease

tremor, stiffness, akinesia

bradykinesia, fatigue, depression

Death of dopaminergic neurons in pars compacta

Impacts motivation

Hunger fails to initiate movements

“Paralysis of will”

kinesia paradoxica

Moves easily in emergency

Immobile after issue passed

Animal with severe basal ganglia damage won’t move toward food

Even if placed within inches

Chew & swallow if put in mouth

Why neurons die is unknown

unique susceptibility?

abnormalities in mitochondrial?

result in abnormal protein handling and neuron death

Dopaminergic neurons in pars compacta contain less calbindin

protein involved in calcium ion transport within cells

excess calcium in cells is toxic

Plasticity of pars compacta is robust

no symptoms until 50-80% of pars compacta dopaminergic neurons have died

  1. Pars Reticulata

output to rest of brain

spontaneously fire action potentials

inhibits targets of basal ganglia

decreases in inhibition are associated with movement

Parkinson’s and epilepsy

Altered patterns of firing

single-spike

burst firing

   Schizophrenia

Patients have increased levels of dopamine

dopamine antagonists remain a standard and successful treatment for schizophrenia

Substantia nigra’s pars compacta

reduction in synaptic terminal size

more active NMDA receptors

reduced dysbindin expression

 

   Wooden Chest Syndrome

aka, fentanyl chest wall rigidity syndrome

rare side effect of synthetic opioids (ie Fentanyl)

generalized increase in skeletal muscle tone

increased dopamine release and decreased GABA release in substatia nigra/striatum

most pronounced on chest wall muscles

leads to impaired ventilation

most common in anesthesia where rapid and high doses given intravenously

 

   Cocaine

inhibition of dopamine reuptake

cocaine is more active in VTA than substantia nigra

increases metabolism in substantia nigra

altered motor function

also inhibits spontaneous firing by the pars compacta

inactivation of substantia nigra as treatment for cocaine addiction?

 

  1. Subthalamic nucleus (also called Luys’ Body)

Input from striatum & cerebral cortex

Output to the globus pallidus

Small lens-shaped nucleus; major part of subthalamus

Functionally part of basal ganglia

Location

ventral to thalamus

dorsal to  substantia nigra

medial to internal capsule

Discovered 1865, by Jules Luys

Structure

long sparsely-spiny dendrites

elliptical dendritic arbors

Spontaneously firing cells

Pace-maker of the brain?

Oscillatory and synchronous activity

Stimulated to treat Parkinson’s

causes nearby astrocytes to release ATP

precursor to adenosine

catabolic process

Damage

small vessel stroke in patients with diabetes, hypertension, or a history of smoking

produces hemibaliismus

uncontrollable flinging movements of arms and legs

Functions

impulse control

OCD cause?

action selection?

 

Basal ganglia all work together

Impacts

Eye movements

Action selection

Voluntary motor control

Inhibits motor systems

Procedural learning

Eye movements

Habits

Lots of brain regions work

 

 

Basal ganglia impacts implicit learning

Action selection?

Which behavior to do when?

Parkinson’s

Cerebral palsy

Damage to basal ganglia during 2nd and 3rd trimester

Foreign accent syndrome

Some combination of problems in cerebellum, Broca’s area & basal ganglion

Caused by stroke or injury

Mispronunciation of words

Listener’s hear it as accent

Not new vocabulary

Sufferer’s may imitate other aspects to normalize syndrome

Basal Gabglia

Movement requires several brain systems to work together. Smooth movements that involve both arms and legs requires the cerebellum to active its GO signals and the basal ganglia to regulate its STOP signals. The frontal lobe and the parietal lobe work together to trigger and guide movement.

Complex or rapid movement sequences involve the combined effort of the supplemental motor cortex, the premotor cortex, the posterior parietal lobe and the primary motor cortex. The two hemispheres also have to exchange information. There is a lot going on.

Neural clusters in peripheral nervous system are ganglia. In the central nervous system, they are called nuclei. Should be called Basal Nuclei but usually called Basal Ganglia

  • limbic
  • The limbic system is a combination of the thalamus, hypothalamus, pituitary and basal ganglia or nuclei. Not well understood but highly interconnected, these structures indirectly regulate a lot of behavior.

Thalamus

Hypothalamus

Pinal Gland

  • Why do we spend 1/3 of our lives being unconcious?

    Sleep is an automatic process we try to control but probably need to increase.

    We get so focused on our tasks and activities, we try to limit the amount of sleep we get. But this mysterious process of sleep is not optional. It’s good for us.

  • Basal Ganglia
  • Neural clusters in peripheral nervous system are ganglia. In the central nervous system, they are called nuclei. Should be called Basal Nuclei but usually called Basal Ganglia.
  • brain’s brake
  • Amygdala
  • Hippocampus

Other Structures

Anterior Cingulate Cortex

Corpus Callosum

Hippocampus

  • Spatial Memory
    • Hippocampal neurons
      • spatially tuned
      • to particular spatial locations
    • Cab drivers
      • Larger than normal posterior hippocampus
    • When answering spatial Qs
      • hippocampus activated
    • Need to recall detail & context
    • Recent memories have sig detail
    • Recalling recent memories
      • activates hippocampus
    • Recalling older memories
      • may not require hippocampus

****

Processes: Brain in action

Brain Waves

  • brain waves
    • beta
    • alpha
    • theta
    • delta
    • SMR (synchronous sensorimotor rhythm (inhibits movement)
    • gamma (meaning & meditative awareness)
    • REM

Patterns

  • bottom up processing
    • detect features
    • put together
    • form image
    • recognize
  • top down processing
    • check for language
    • words vs sounds
    • Stroop effect
    • Interpreting context

Movement

This is a good example of many parts of the body working together

 

  • Primary Motor Cortex (con’
    • Posterior parietal cortex
      • Planning a movement
      • Keeps track of body position
      • Intention to move
      • Damage causes
        • trouble converting visual perceptions into actions
        • trouble finding objects in space
    • Supplemental Motor Region
      • Plan-organize rapid sequences
        • pushing, pulling, and then…
      • Mirror Neurons
      • Function
        • Preparing to do movement
        • Watching someone else do it
        • Type of cell or function?
        • Some innate
        • Some acquired by experience
        • Imitating & understanding others
        • Modeling
  • 2. Pre-Motor Cortex
    • Preparing for movement
    • Somewhat active during move
    • Receives info about
    • Where target is in space
    • Current position of your body
    • Damage
      • Poorly planned movements

Cognition

Cognition includes thinking, problem solving, sensing and language. We use both hemispheres to perform these functions.

Brain localization is often overstated. Most people have language stored in the left hemisphere but it doesn’t mean that the right hemisphere isn’t also functioning. There are few clear-cut distinctions. We use the whole brain.

Language and thought are difficult to research. Much of our knowledge comes from individuals who have had injuries, strokes or other impairments. Putting together a coherent theory from a model of disable people is hard.

Intelligence

Our definition of “brain” has changed of the last few years. Now, your car, house and washing machine are “smart” and run by an electronic brain. But artificial intelligence isn’t the only kind of intelligence there is.

Intelligence

Animal

Human

Artificial

  • Rube Goldberg
  • Turing test
    • Doesn’t show understanding
    • mindless manipulation of symbols
    • phone
  • Neural networks
    • Collection of algorithms
    • Try to recognize patterns
    • labeling
    • clustering
    • similarity detection
    • Real-world data is translated into vectors
    • Predictions with linear regression
  • Deep learning networks
    • multilayer (more than 1 layer)
    • must pass through more nodes
    • cluster 1 million photos
    • cats, cars, citrus
    • automatic feature extraction
    • trained on labeled data
    • run on unlabeled data
  • Big Blue didn’t recognize decades

Learning

Memory

Learning and memory go together. And you already know how to use them. You use them all the time.

A great learning theorist (me) has said there are only three types of things you can learn: facts, concepts and behaviors. Each uses a different part of the brain and require different techniques. But they all work together.

Facts was difficult to remember if they are unstructured. Ebbinghaus showed that we forget lists of unrelated words very quickly. This tells us that to remember facts (the kind of things that appear on tests) organizing them into clusters and meaningful units is really important.

Attack and escape behaviors and related to fear and anxiety. Anxiety disorders are an extension or over-activation of our normal processes.

Conceptual learning refers to our ability to learn rules. When you are three years old, you can learn a rule but have difficulty changing to a new rule. When you are four years old, you can use different rules as needed.

Learning behaviors involves our implicit memory system. We learn skills and habits by practicing them. Their forgetting curve is quite different from the one that describes learning lists of facts.

Thinking and memory aren’t the same thing but highly related. Human memory is composed of several systems. It’s not a single process. Memory involves nearly every part of the brain, both sides.

The two hemispheres are connected by the corpus collosum. This bundle of neurons keeps our two super computers in touch with each other. One side names the object that your other side is reaching for. It’s teamwork.

  • Memory Systems
    • Procedural Memory
      • What you can do
    • Sensory Memory
      • Buffers for vision & audition
    • Prospective Memory
      • Remember what going to do
      • Sensitive to elderly
    • Declarative (things you know)
      • Episodic (life story of events)
        • right hemisphere
      • Semantic (names and facts)
        • left hemisphere
  • Non-Declarative Memory
    • Doesn’t use hippocampus
    • Non-word learning
    • Acquired slowly
    • Includes
    • conditioned responses
    • skills
    • habits
    • priming
  •  Types of Memory
    • Short-term memory
      • Memory of events just occurred
      • About seven items (+-2)
      • Rehearsal to get it in
      • Once gone, lost forever
    • Long-term memory
      • Memory of previous events
      • Long-term memory is vast
      • Difficult to estimate how big
      • Rehearsal not needed
      • May recall with hints
    • STM can be moved to LTM
      • Held in working memory
      • If score changes, throw out old score
    • Consolidation
      • Varies widely between people & material
      • Interesting facts more than boring
      • Emotional items learned quickly
        • Cortisol activates
          • Amygdala
            • storage of emotional events
          • Hippocampus
            • Consolidates emotional event
      • LTM not permanent
        • Change, fade & vary in detail
        • Reconsolidate a memory if:
        • A reminder followed by similar experience
        • New experiences during reconsolidation can modify memory
  • Working Memory
    • Temporary storage of tasks
    • Attending to right now
    • Delayed-response task
      • Ss given signal
      • Give response after a delay
      •  Damage to prefrontal cortex
        • Impairs working memory tasks
      • Older people often have impaired working memory
        • Prefrontal cortex may change as age?

Emotion

Emotion is a common phenomenon but not well understood. We have emotions; we just don’t understand them.

Emotion goes with autonomic arousal. When we sense danger (real or not), the hypothalamus and limbic system kick in, releasing cortisol, epinephrine and other agents to ready us for action. This is part of our fight-flight-freeze system.

Attack and escape behaviors and related to fear and anxiety. Anxiety disorders are an extension or over-activation of our normal processes.

Stress keeps us alert to damage but makes it difficult to sleep. Sleep apnea, for example, causes higher blood sugar and cortisol levels. The short lapses of breathing trigger our protective arousal system.

When I see a bear do I run because I’m afraid or am I afraid because I run?As it turns out, there are more than two answers to this classic riddle. Emotions are part of our human experience and central to our understanding of how we see ourselves.But there are multiple theories of emotion and no clear answers. But it appears that thinking is more important to feeling than we thought it was.Here’s what is included in this lesson:

how to identify emotions in animals

how to identify emotions in people

amygdala and its role in emotions

theories of emotion

basic emotions

Epilepsy

Head Injuries

Hormones

Intelligence

Motivation

  • Emotions
    • state dependent learning
  • Motivation
    • get you off the couch

Reward System

 

 

 

 

Here’s what is included in this lesson:

  • Phineas Gage
  • Stroop effect and top-down processing

 

Disorders

Cerebellum Syndrome

Memory Disorders

Mood Disorders

Schizophrenia

Parkinson’s

Alzheimer’s

Addition

MS

ALS

PKU

Amnesia

    • Memory loss
      • Better Implicit Memory
      • Nearly all patients with amnesia show better implicit memory
      • Impact of recent experience on behavior
        • even if not realize using memory at all
      • Not good at deliberate recall
      • Good at doing without knowing
  • Usually
    • better implicit than explicit
    • normal working memory
    • nearly intact procedural memory
    • some retrograde amnesia
    • severe anterograde amnesia
  • Hippocampal damage
    • Impairs performance on
      • Delayed matching-to-sample tasks
        • Task used in animals
        • Animals see an object (sample)
        • After a delay choose between two objects
        • Goal: choose one matches the sample
      • Delayed nonmatching-to-sample tasks
        • Same procedure
        • Except animal must choose the different object

 

Filed Under: BioPsych

‘There are two great principles of psychology: people have a tremendous capacity to change, and we usually don’t.”   Ken Tangen

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