- Sleep
- Don’t know why the body requires sleep
- Know
- lack of sleep is linked to higher risk of
- depression
- heart disease
- aggravates mental illness
- mammals & birds sleep
- lack of sleep is linked to higher risk of
- Stages
- NREM
- N1
- N2
- N3 (delta) = slow wave; deep sleep
- REM
- NREM
- Historically:
- Alfred Loomis (1887-197
- Lawyer, inventor,
- RADAR, microscope centrifuge
- lab in Tuxedo Park
- Dement & Kleitman, 1953
- REM sleep plus 4 NREM
- Alfred Loomis (1887-197
- Now, 3 stages plus REM
- combined stages 3 and 4
- Stages based on EEG, eye movements, respiratory, cardiac, and movement events
- Cycles
- N1→N2 →N3 →N2 →REM
- proportion of REM sleep increases until just before natural awakening
- In humans (adults), sleep cycle from 90 to 110 min.
- 60 minutes for newborns
- Awake
- Close eyes
- meditating
- alpha waves
- still awake & aware
- 8-13 HZ
- Stage N1
- Somnolence or drowsy sleep
- Twitches and jerks
- Hallucinations
- Lower awareness
- Theta waves
- higher amplitude than alpha
- slower frequency 6–7 Hz.
- light sleep
- 5-10 min\
- Stage N2
- About 50% of sleep time
- Theta waves (same as stage 1)
- less movement, less awareness
- body temperature drops
- heart rate slows
- Two additions (discovered by Loomis)
- K complexes
- Sleep spindles
- K-Complex
- Brief high-voltage peaks
- roughly every minute
- often followed by bursts: sleep spindles
- Suppress cortical arousal, except to danger signals
- Aid memory consolidation
- Sleep Spindles
- AKA “sigma bands” or “sigma waves”
- last half second
- sudden bursts
- usually 12-14 Hz
- less movement, no awareness
- Stage N3
- Deep or slow-wave sleep
- Bed wetting
- Sleep walking
- Sleep talking
- Night terrors
- Delta waves
- Lowest frequency waves 4-7 Hz
- Highest amplitude
- Used to be called stages 3 & 4
- minimum is 20% delta
- less than 50% delta
- more than 50% delta
- Body repairs itself
- builds bone & bone
- strengthen immune system
- Deep or slow-wave sleep
- REM
- Rapid eye movement sleep
- 20–25% of total sleep time
- rapid low-voltage EEG
- Combination of
- alpha waves
- delta waves
- desynchronous waves (like beta)
- As night progresses
- Less delta waves
- desynchronous waves (like beta)
- Heart rate rises
- Breathing is faster, shallow, irregular
- Like being awake
- more acetylcholine
- But no monoamines
- dopamine, norepinephrine, etc
- serotonin, histamine
- Paralysis
- If asleep
- inject acetylcholinesterase inhibitor
- paradoxical sleep
- If awake
- paradoxical sleep only if monoamines depleted
- If asleep
- GABA (amino acid)
- promotes wakefulness
- diminishes during deep sleep
- increases during REM
- Glycine (amino acid) increases too
- Both
- ionotropic GABA (respond to glycine)
- metabotropic GABA receptors (respond to GABA)
- First REM of night
- ~90 minutes after fall asleep
- After 1st cycle
- more as night goes on
- first lasts 10 minutes
- final 60+ minutes
- Relatively little dreaming in NREM
- Lucid dreams in REM
- Memorable dream